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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Hoe 140
Cat. No. PN-090
Structure:
H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH
Other Names:
Icatibant
Activity:
Bradykinin B2 receptor antagonist
Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.
Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851
Perkins et al (1993) Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain 53(2) 191 PMID: 8393171
Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984
Related areas
All peptides >
All bradykinin receptor modulators >
All pain research categories >
Technical Data
| Structure | H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH |
| CAS Number | 130308-48-4 |
| Molecular Weight | 1304.5 |
| Formula | C59H89N19O13S |
| Sequence | RRPXGXSXXR |
| Modifications | Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Hoe 140 MSDS_602be17182018.pdf |
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