Search
0
Items
Select
Search
MENU
Select

Ion channel modulators

Ion channels are pore-forming membrane proteins which allow the passage of ions in and out of a cell through the plasma membrane, with hundreds of different types of ion channel being identified in the membranes of all biological cells.  Ion channels can be classified by different properties, including by the gating mechanism or the ion selectivity of the pore.  Ion channels classified by gating mechanism include voltage-gated ion channels, ligand-gated ion channels, light-gated ion channels, mechanosensitive ion channels, cyclic nucleotide-gated ion channels, calcium-gated ion channels and ions classified by ion selectivity include calcium, potassium, sodium, chloride, protons and non-selective.  Ion channels are essential for life and play a fundamental role in physiological processes such as muscle contraction and nutrient transport.  A multitude of diseases result from the disruption of normal ion channel function. 

Further reading

Camerino et al (2007) Ion channel pharmacology. Neurotherapeutics 4 184 https://doi.org/10.1016/j.nurt.2007.01.013

Ion Channels. (2011) Br. J Pharmacol.164(Suppl 1):S137 doi: 10.1111/j.1476-5381.2011.01649_5.x. PMCID: PMC3315630

Kadir et al (2018) Emerging Roles of the Membrane Potential: Action Beyond the Action Potential. Front Physiol. 9 1661 doi:10.3389/fphys.2018.01661


Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

Tel: (+44) 01392 422205

Fax: (+44) 01392 279510


[email protected]