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Regulated cell death

Regulated cell death is a process in organisms that is essential for tissue homeostasis or to restore equilibrium following stress.  Unlike acccidental cell death, regulated cell death involves tightly ordered signalling cascades and well defined effector mechanisms.  Multiple cell death pathways have been defined including apoptosis, autophagy, necrosis, necroptosis, pyroptosis, ferroptosis, entotic cell death, lysosome-dependent cell death, alkaliptosis, oxeiptosis, and netotic cell death. The loss of control of regulated cell death contributes to neurodegeneration, autoimmune and infectious diseases, and cancer.

Further reading

Tang et al (2019) The molecular machinery of regulated cell death. Cell. Res. 29 347 https://doi.org/10.1038/s41422-019-0164-5

De Re et al (2019) Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease. Physiological Rev. 99(4) 1765

Flores-Romero et al (2020) A lipid perspective on regulated cell death. International Rev. Cell Molecular Biol. 351 197 ISSN 1937-6448,

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