Nuclear receptor modulators

Nuclear receptors are a family of ligand-regulated transcription factors that are activated by one of two main classes of ligands, steroid hormones - such as estrogen and progesterone - and non steroidal ligands, including retinoic acid and thyroid hormone.  A number of nuclear receptors have no known endogenous ligands and are considered orphan receptors, these include FXR, LXR, and PPAR.  Instead these receptors bind with low affinity to a number of metabolic intermediates and may function as metabolic sensors.  A unique property of nuclear receptors is their ability to directly interact with and regulate transcription of genes, which allows them to control a wide variety of biological processes, such as the cellular response to sex steroids, vitamin D3, adrenal steroids and other metabolic ligands.
Biotin labelled peptides
Cat No. Product Name Activity
PI-020 SRC-1 (676–700), biotinylated Biotinylated peptide derived from the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1

Robinson-Rechavi et al (2003) The nuclear receptor superfamily.  J. Cell Sci. 116: 585 doi: 10.1242/jcs.00247

Sever and Glass (2013) Signaling by nuclear receptors. Cold Spring Harb. Perspect. Biol. 5(3) a016709 PMID: 23457262

Alexander et al (2019) The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br.J. Pharmacol. 176 (S1) S229

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