Transporters are membrane-spanning proteins that facilitate the movement of lipids, sterols, ions, small molecules, drugs, amino acids, sugars and large polypeptides across biological membranes. Transport can be passive or active. Passive transport follows a concentration gradient so requires no energy input and is further divided into two types - diffusion, which is spontaneous movement across the membrane and facilitated transport. In contrast active transport requires energy to transport substances into a cell. Membrane transporters can be also divided into three main classes; ABC transporters, P-type ATPases and the solute carrier family (SLC).   Inhibitors of transporters have proved useful in the treatment of a variety of disorders, including depression (SERT), epilepsy (GABA transporter) and Parkinson's disease (DAT) 

Further reading

The International Transporter Consortium (2010) Membrane transporters in drug development. Nat. Rev. Drug Discov. 9 215

DeGorter et al (2012) Drug Transporters in Drug Efficacy and Toxicity. Ann. Rev. Pharmacol. Toxicol. 52(1) 249

Alexander et al (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. Br. J. Pharmacol. 176 S397 doi: 10.1111/bph.14753

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