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Epitopes

An epitope is the part of an antigen that is recognized by the immune system.   Epitopes are relatively short sequences of amino acids and a typical full-length protein contains many different epitopes to which antibodies can bind.  Epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope, the region of an antibody to which an epitope binds.   The immune system is divided into innate and adaptive categories, adaptive immunity is only present in vertebrates and highly selectively recognises, destroys and remembers invading pathogens in a process mediated by T- and B-cells. B- and T-cells do not recognize pathogens as a whole, but instead recognize epitopes within these antigens. Epitopes are classified as B cell epitopes or T cell epitopes on the basis of the types of cellular response they elicit. There is great interest in identifying epitopes in antigens in order to understand disease etiology, for immune monitoring, to develop diagnosis assays, and to design epitope-based vaccines.

Myelin peptides
Cat No. Product Name Activity
NR-010 MOG (35-55) (human) Fragment of human myelin oligodendrocyte glycoprotein (MOG)
NR-020 MOG (35-55) (rat) Highly encephalitogenic fragment of myelin oligodendrocyte glycoprotein
NR-120 Myelin Basic Protein (85-99) peptide antagonist Candidate autoantigen in multiple sclerosis
NR-030 PLP (139-151) Induces severe experimental allergic encephalomyelitis (EAE)
NR-040 [Leu144, Arg147]-PLP (139-151) T cell receptor antagonist
NR-130 [Ser140]-PLP (139-151) Induces acute autoimmune encephelomyelitis (EAE)
Peptides
Cat No. Product Name Activity
IM-040 IRBP (1-20) (human) N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP)
IM-050 IRBP (651-670) (human) Residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP)
EP-010 OVA (257-264) Antigenic ovalbumin peptide fraqment 

Further reading

Huang and Honda (2006) CED: a conformational epitope database. BMC Immunol. 7 7 doi:10.1186/1471-2172-7-7

Sanchez-Trincado et al (2017) Fundamentals and Methods for T- and B-Cell Epitope Prediction J. Immunology Research Article ID 2680160 https://doi.org/10.1155/2017/2680160

Tian et al (2018) A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis. Front. Immunology 9 2778 https://www.frontiersin.org/article/10.3389/fimmu.2018.02778

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