Protein-protein interactions

Protein–protein interactions (PPIs) play a central role in many biological pathways and processes.  While many proteins perform their functions independently, the vast majority interact with others for proper biological activity.  Important protein-protein interactions are found with chaperone proteins, heat shock proteins, microtubules, transcription factors, immune checkpoint proteins and cytokines.  There are currently more than 400,000 known PPIs, and these interactions make up the interactomics of the organism, known as the interacterome.  Aberrant protein-protein interactions are associated with several human diseases, notably those associated with epigenetics, immunology and cancer, and are also are the basis of multiple aggregation-related diseases, such as Creutzfeldt–Jakob and Alzheimer's disease.

Biotin labelled peptides
Cat No. Product Name Activity
PI-010 H10, biotinylated Biotinylated version of anterior gradient 2 (AGR2) binding peptide H10
PI-020 SRC-1 (676–700), biotinylated Biotinylated peptide derived from the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1
Cell penetrating peptides
Cat No. Product Name Activity
PI-090 P110 Drp1 enzyme inhibitor and blocker of  Drp1/Fis1 interaction
PN-200 TAT-AKAP79 (326-336) The key region of AKAP79 for interaction with TRPV1
PN-160 TAT-CBD3 CRMP2 - CaV2.2 interaction inhibitor
PN-180 TAT-CBD3A6K Optimised variation of CBD3
PI-040 Tat-βsyn-degron α-Synuclein knockdown peptide
Cat No. Product Name Activity
PN-190 736-745-TAT Inhibits the interaction of TRPV1 and AKAP79
PI-060 Bak BH3

Bak BH3 sequence that binds to Bcl-xL

PI-080 Bid BH3  Fragment of the BH3 domain of BID
PI-070 Bim BH3 BH3 only protein Bim fragment
IM-010 CXCL8 (54-72) C-terminal CXCL8 peptide fragment corresponding to the core CXCL8 - glycosaminoglycan (GAG) binding region
IM-020 CXCL8 (54-72) scrambled control Scrambled version of CXCL8 (54-72) for use as a control
IM-015 E70K Inhibits CXCL8-induced neutrophil transendothelial migration
PI-030 KSL 128114 Binds the PDZ1 domain of syntenin
PN-170 Myr-tat-CBD3 Blocks the  CaV2.2–CRMP2 interaction
AM-180 N-peptide Binds the periplasmic chaperone protein chaperone SurA
PI-050 PUMA BH3 BH3 domain fragment of PUMA.
KS-120 R18 4.3.3 proteins antagonist
CV-050 SBP1 Binds to the SARS-CoV-2 receptor binding domain
PN-130 T100-Mut Enhances the association of TRPA1 and TRPV1

Further reading

De Las Rivas and Fontanillo (2010) Protein-protein interactions essentials: key concepts to building and analyzing interactome networks. PLoS Comput. Biol. 6(6) e1000807 doi:10.1371/journal.pcbi.1000807

Titeca et al (2019) Discovering cellular protein‐protein interactions: Technological strategies and opportunities. Mass Spec. Rev. 38 79

Scott et al (2016) Small molecules, big targets: drug discovery faces the protein–protein interaction challenge. Nat. Rev. Drug Discov. 15  533

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