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Ubiquitin-proteasome system

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes.  The ubiquitin-proteasome system consists of many factors that include E3 ubiquitin ligases, ubiquitin hydrolases, ubiquitin and ubiquitin-like molecules, and the proteasome itself.  The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress.

Further reading

Muratani and Tansey (2003) How the ubiquitin–proteasome system controls transcription. Nat. Rev. Mol Cell Biol. 4 192 https://doi.org/10.1038/nrm1049

Lecker et al (2006) Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States. JASN 7(7) 1807 DOI: 10.1681/ASN.2006010083

Gong et al (2016) The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury. Front. Molecular Neurosci. 9 4 DOI=10.3389/fnmol.2016.00004

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