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TAT-AKAP79 (326-336)

Cat. No. PP-130

Structure:

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Ser-Lys-Ser-Glu-Glu-Ser-Lys-Arg-Met-Glu-OH

Activity:

The key region of AKAP79 for interaction with TRPV1
Price Qty
1 mg    $ 189.00
TAT-AKAP79 (326-336) is amino acids 326–336 of A-kinase anchoring protein 79 (AKAP79), the human anchoring protein, fused to TAT to promote uptake across the cell membrane. AKAP79 (326-336) is the the key region of AKAP79 for interaction with transient receptor potential vanilloid 1 (TRPV1), the thermo-TRP ion channel activated by painful levels of heat, and AKAP79 binding to TRPV1 blocks TRPV1 sensitization. TAT-AKAP79 (326-336) inhibits inflammatory hyperalgesia in mice.

Btesh et al (2014) Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia. J Neurosci. 33(21) 9184 PMID: 23699529


Related areas

All protein-protein interaction modulators >
All transient receptor potential (TRP) channel modulators >
All cell penetrating peptides >
All pain research categories >


Technical Data

Structure H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Ser-Lys-Ser-Glu-Glu-Ser-Lys-Arg-Met-Glu-OH
Molecular Weight 2880.34
Formula C117H211N49O34S1
Sequence YGRKKRRQRRRKSKSEESKRME
Modifications None

Solubility and Storage

Solubility Soluble in DMSO
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC

Contact Information

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