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Substance P

Cat. No. NR-140

Structure:

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Other Names:

Neurokinin-1

Activity:

Endogenous neurokinin-1 receptor (NK1R) agonist
Price Qty
5 mg    $ 115.00
Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.

Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370

Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689

Zieglgänsberger (2019) Substance P and pain chronicity. Cell Tissue Res. 375(1) 227 PMID: 30284083


Related Areas

All peptides >
All tachykinin receptor modulators >
All pain research categories >
All neuroscience research categories >
All immunology research categories >


Technical Data

Structure H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
CAS Number 33507-63-0
Molecular Weight 1347.6
Formula C63H98N18O13S
Sequence RPKPQQFFGLM-NH2
Modifications C terminal amide

Solubility and Storage

Solubility Soluble in dilute acid and physiological buffers
Appearance Freeze dried solid
Storage We recommend storage desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC
Certificate of Analysis Substance P PRN0628-200504 Product Datasheet_602d0ba9db326.pdf

Contact Information

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