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LIH383

Cat. No. PN-220

Structure:

H-Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2

Activity:

Atypical chemokine receptor (ACKR3) agonist which can potentiate opioid peptide activity
Price Qty
1 mg    $ 129.00
LIH383 is a highly selective agonist of the atypical chemokine receptor, ACKR3 (formerly known as CXCR7). Functionally, ACKR3 is a scavenger receptor for a wide variety of opioid peptides, especially enkephalins and dynorphins, reducing their availability for the classical opioid receptors. LIH383 competes directly with CXCL12-AF647 for ACKR3 binding at low nanomolar concentrations and is more potent in inducing β-arrestin recruitment to ACKR3 than the full-length chemokine ligands CXCL12 and CXCL11, with EC50 values of 1.2 nM and 2.2 nM respectively, and no effect on of any other opioid or chemokine receptor at concentrations up to 3 µM.  LIH383 can restrain the negative regulatory function of ACKR3 on opioid peptides and potentiate their activity in rat brain.
Meyrath et al (2020) The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat. Commun. 11 3033 https://doi.org/10.1038/s41467-020-16664-0

Technical Data

Structure H-Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2
Molecular Weight 997.23
Formula C45H72N16O8S
Sequence FGGFMRRK-NH2
Modifications Amide at C terminal lysine

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC
Safety Data Sheet LIH383 MSDS_602be5b9154f4.pdf

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

Tel: (+44) 01392 422205

Fax: (+44) 01392 279510


[email protected]