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α-Calcitonin gene related peptide (human)
Cat. No. CG-010
Structure:
Other Names:
Activity:
α-Calcitonin gene related peptide (human) is a potent, long-lasting vasodilator which possesses protective mechanisms for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and can function in the transmission of nociception. α-Calcitonin gene related peptide (human) acts as an appetite suppressant and contributes to gastric acid secretion.
Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554
Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233 PMID: 12037140
Russell et al (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 94(4) 1099 PMID: 25287861
Related areas
All peptides >
All calcitonin and related receptor modulators >
All endocrinology research areas >
All cardiovascular research categories >
All appetite regulation research categories >
All pain research categories >
Technical Data
Structure | H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2, disulfide bridge between cysteines 2 and 7 |
CAS Number | 90954-53-3 |
Molecular Weight | 3789.33 |
Formula | C163H267N51O49S2 |
Sequence | ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 |
Modifications | C-terminal amide, disulfide bridge between cysteines 2 and 7 |
Solubility and Storage
Solubility | Soluble to 0.50 mg/ml in water |
Appearance | Freeze dried solid |
Storage | Store dessicated, frozen and in the dark |
Batch Specific Data
Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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