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KSL 128114

Cat. No. PI-030

Structure:

Ac-arg-Arg-arg-Gly-arg-Lys-lys-Arg-arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH

Activity:

Binds the PDZ1 domain of syntenin
Price Qty
1 mg    $ 289.00
KSL 128114 is a potent, and metabolically stable peptide inhibitor of syntenin, which binds the PDZ1 domain of syntenin with nanomolar affinity.  KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and shows an inhibitory effect on primary glioblastoma cell viability.  KSL 128114 significantly extends survival time in a patient derived glioblastoma xenograft mouse model.
Haugaard-Kedström et al (2021) A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma.  J.Med.Chem. 64 1423

Technical Data

Structure Ac-arg-Arg-arg-Gly-arg-Lys-lys-Arg-arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH
Molecular Weight 2201.6
Formula C94H163N39O20
Sequence Ac-rRrGrKkRrSHW(Tle)(Chg)DI
Modifications N terminal is acetylated, arginines 1, 3, 5 and 9 and lysine 7 are D amino acids, Tle is tert butyl glycine and Chg is cyclohexylglycine

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95%

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

Tel: (+44) 01392 422205

Fax: (+44) 01392 279510


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