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P32/98

Cat. No. PI-090

Structure:

(2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate

Other Names:

Isoleucyl thiazolidide

Activity:

Dipeptidyl peptidase IV (DPP IV) inhibitor
Price Qty
P32/98, also known as isoleucyl thiazolidide, is a potent and selective cell permeable inhibitor of dipeptidyl peptidase IV (DPP IV) with a Ki of 130 nM. P32/98 inhibition of DPP IV prevents degradation of both gastric inhibitory peptide (GIP) and Glucagon-like peptide-1, enhancing insulin secretion. P32/98 improves glucose tolerance, insulin sensitivity and beta-cell glucose responsiveness in diabetic fatty rats following oral administration.

Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47 1253 PMID: 9703325

Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral Ins sensitivity in the VDF Zucker rat. Diabetes 51 2677 PMID: 12196458

Wagner et al (2016) Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation. Neuropeptides. 57 21 PMID: 26988064


Related areas

All small molecules >
All dipeptidyl peptidase IV modulators >
All diabetes research categories >


Technical Data

Structure (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate
CAS Number 136259-20-6
Molecular Weight 260.35
Formula C9H18N2OS 1/2C4H4O4
Sequence (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate

Solubility and Storage

Solubility Soluble in DMSO or in water (up to 20 mg/ml).
Appearance White solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity 98% by tlc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

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France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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