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WP 1130

Cat. No. PI-240

Structure:

(2E)​-3-​(6-​bromo-​2-​pyridinyl)​-​2-​cyano-​N-​[1S-​phenylbutyl]​-2-​propenamide

Other Names:

Degrasyn

Activity:

Deubiquitinase (DUB) inhibitor
Price Qty
10 mg    $ 115.00
WP 1130, also known as degrasyn, is a cell-permeable deubiquitinase (DUB) inhibitor, able to directly inhibit the DUB activity of USP9x, USP5, USP14, and UCH37. WP 1130 has been shown to downregulate both wild-type and mutant Bcr/Abl without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. WP 1130 can cause marked anti-proliferative activity and morphological changes in NCH644 and NCH421K glioma stem-like cells.

Bartholomeusz et al (2007) Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. 109(8) 3470 PMID: 17202319

Bartholomeusz et al (2007) Degrasyn activates proteasomal-dependent degradation of c-Myc. Cancer Res. 67(8) 3912 PMID: 17440106

Kapuria et al (2010) Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res. 70(22) 9265 PMID: 21045142


Related areas

All small molecules >
All  deubiquitinating enzyme modulators >
All cancer research categories >


Technical Data

Structure (2E)​-3-​(6-​bromo-​2-​pyridinyl)​-​2-​cyano-​N-​[1S-​phenylbutyl]​-2-​propenamide
CAS Number 856243-80-6
Molecular Weight 384.30
Formula C19H18BrN3O
Sequence (2E)​-3-​(6-​bromo-​2-​pyridinyl)​-​2-​cyano-​N-​[1S-​phenylbutyl]​-2-​propenamide

Solubility and Storage

Solubility Soluble in DMSO and ethanol
Appearance White solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >98% by HPLC

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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