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Products
Pharmacology
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- Ordering
- About Us
- Technical support
- Resources
DC432
Cat. No. EI-020
Structure:
4-Hydroxyphenylacetyl-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2
Activity:
N-terminal methyltransferase1/2 (NTMT1/2) inhibitor, cell permeable
DC432 is a cell permeable analogue of BM30, also available, the first potent peptidomimetic substrate competitive inhibitor of N-terminal methyltransferase1/2 (NTMT1/2), one of a family of enzymes which methylate the α-N-terminal amines of proteins starting with the canonical X-P-K/R motif. DC432 has been made cell permeable by the addition of five arginine residues to BM30. DC432 decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.
Mackie et al (2020) Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 63(17) 9512 doi:10.1021/acs.jmedchem.0c00689
Technical Data
| Structure | 4-Hydroxyphenylacetyl-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2 |
| Molecular Weight | 1313.59 |
| Formula | C55H100N28O10 |
| Sequence | XPKRRRRRR-NH2 |
| Modifications | C terminal amide, X is 4-hydroxyphenylacetyl |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | DC432 MSDS_602bbbe143604.pdf |
Contact Information
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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