How to dissolve peptides

Where possible we provide specific solubility instructions for dissolving peptides. If specific instructions are not available, the following guidelines can be used. Most peptides are soluble in distilled water. If they do not completely dissolve, the addition of 1.0 M acetic acid for basic peptides (those containing arginine, lysine or histidine) or 1.0 M ammonium hydroxide for acidic peptides (those containing aspartic acid or glutamine) may help. Solubilisation of extremely insoluble peptides can be assisted with 10% DMSO, although the use of DMSO as co-solvent may interfere with some biological assays. Sonication can also be a useful aid for solubilizing peptides. When solubilizing peptides, it is recommended that the peptide be dissolved to the highest possible concentration, and then diluted with water or buffer to the working concentration. The buffer should only be added when the peptide is completely solubilized as salts may cause aggregation

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